The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia

1. The human HERG gene encodes the cardiac repolarizing K(+) current I(Kr) and is genetically inactivated in inherited long QT syndrome 2 (LQTS2). The antihistamine terfenadine blocks HERG channels, and can cause QT prolongation and torsades de pointes, whereas its carboxylate fexofenadine lacks HER...

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Autori principali: Scherer, Constanze R, Lerche, Christian, Decher, Niels, Dennis, Adrienne T, Maier, Patrick, Ficker, Eckhard, Busch, Andreas E, Wollnik, Bernd, Steinmeyer, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2002
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573545/
https://ncbi.nlm.nih.gov/pubmed/12411421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704873
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