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DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration

1. We identified the ethacrynic-acid derivative DCPIB as a potent inhibitor of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM. Similarly, 10 μM DCPIB almost completely inhibited the swelling-induced chloride conductance...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Decher, Niels, Lang, Hans J, Nilius, Bernd, Brüggemann, Andrea, Busch, Andreas E, Steinmeyer, Klaus
פורמט: Artigo
שפה:Inglês
יצא לאור: 2001
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573095/
https://ncbi.nlm.nih.gov/pubmed/11724753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704413
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