DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration

1. We identified the ethacrynic-acid derivative DCPIB as a potent inhibitor of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM. Similarly, 10 μM DCPIB almost completely inhibited the swelling-induced chloride conductance...

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Bibliografiske detaljer
Main Authors: Decher, Niels, Lang, Hans J, Nilius, Bernd, Brüggemann, Andrea, Busch, Andreas E, Steinmeyer, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: 2001
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573095/
https://ncbi.nlm.nih.gov/pubmed/11724753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704413
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