DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration

1. We identified the ethacrynic-acid derivative DCPIB as a potent inhibitor of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM. Similarly, 10 μM DCPIB almost completely inhibited the swelling-induced chloride conductance...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Decher, Niels, Lang, Hans J, Nilius, Bernd, Brüggemann, Andrea, Busch, Andreas E, Steinmeyer, Klaus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2001
Pynciau:
Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573095/
https://ncbi.nlm.nih.gov/pubmed/11724753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704413
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