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The pure anti-oestrogen ICI 182,780 (Faslodex™) activates large conductance Ca(2+)-activated K(+) channels in smooth muscle
Oestrogen and tamoxifen activate large conductance Ca(2+)-activated K(+) (BK(Ca)) channels in smooth muscle through a non-genomic mechanism that depends on the regulatory β1 subunit and an extracellular binding site. It is unknown whether a ‘pure' anti-oestrogen such as ICI 182,780 (Faslodex™),...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573435/ https://ncbi.nlm.nih.gov/pubmed/12145095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704807 |
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