A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway

1. NCX-701 is a nitric oxide (NO)-releasing acetaminophen (APAP) derivative. 2. In the present study we demonstrated that NCX-701 is as effective as APAP in controlling body temperature in a rat model of endotoxin-induced fever. 3. Liver toxicity is a major complication of APAP overdosing. To invest...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Fiorucci, Stefano, Antonelli, Elisabetta, Mencarelli, Andrea, Palazzetti, Barbara, Alvarez-Miller, Lorena, Muscara, Marcelo, del Soldato, Piero, Sanpaolo, Laura, Wallace, John L, Morelli, Antonio
Format: Artigo
Langue:Inglês
Publié: 2002
Sujets:
Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573169/
https://ncbi.nlm.nih.gov/pubmed/11834606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704500
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