N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) suppresses microglial inducible nitric oxide synthase (iNOS) expression and activity induced by interferon-γ (IFN-γ)

1. Microglial cells up-regulate inducible nitric oxide synthase (iNOS) expression in response to various pro-inflammatory stimuli including interferon-γ (IFN-γ), allowing for the release of nitric oxide (NO). Tranilast (N-[3,4-dimethoxycinnamoyl]-anthranilic acid) is an antiallergic compound with su...

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Detalhes bibliográficos
Main Authors: Platten, Michael, Wick, Wolfgang, Wischhusen, Jörg, Weller, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573061/
https://ncbi.nlm.nih.gov/pubmed/11704648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704373
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