Inhibition of acetylcholine-activated K(+) currents by U73122 is mediated by the inhibition of PIP(2)-channel interaction

1. We have investigated the effect of U73122, a specific inhibitor of phospholipase C (PLC), on acetylcholine-activated K(+) currents (I(KACh)) in mouse atrial myocytes. 2. In perforated patch clamp mode, I(KACh) was activated by 10 μM acetylcholine. When atrial myocytes were pretreated with U73122...

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Bibliographic Details
Main Authors: Cho, Hana, Youm, Jae Boum, Ryu, Shin Young, Earm, Yung E, Ho, Won-Kyung
Format: Artigo
Language:Inglês
Published: 2001
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573039/
https://ncbi.nlm.nih.gov/pubmed/11682455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704347
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