Decrease in PIP(2)–channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABA(B)-activated K(+) current

We showed in our previous study that in hippocampal CA1 neurons the stimulation of muscarinic receptors inhibited the GIRK current (I(GIRK)) via a PLC/PKC pathway, whereas group I metabotropic glutamate receptors (mGluR) inhibited I(GIRK) via a PLA(2)/arachidonic acid pathway. In this study, we pres...

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Autori principali: Sohn, Jong-Woo, Lim, Ajin, Lee, Suk-Ho, Ho, Won-Kyung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075246/
https://ncbi.nlm.nih.gov/pubmed/17584838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.137265
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