Protein arginine methylation facilitates KCNQ channel-PIP(2) interaction leading to seizure suppression

KCNQ channels are critical determinants of neuronal excitability, thus emerging as a novel target of anti-epileptic drugs. To date, the mechanisms of KCNQ channel modulation have been mostly characterized to be inhibitory via Gq-coupled receptors, Ca(2+)/CaM, and protein kinase C. Here we demonstrat...

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Publicado no:eLife
Main Authors: Kim, Hyun-Ji, Jeong, Myong-Ho, Kim, Kyung-Ran, Jung, Chang-Yun, Lee, Seul-Yi, Kim, Hanna, Koh, Jewoo, Vuong, Tuan Anh, Jung, Seungmoon, Yang, Hyunwoo, Park, Su-Kyung, Choi, Dahee, Kim, Sung Hun, Kang, KyeongJin, Sohn, Jong-Woo, Park, Joo Min, Jeon, Daejong, Koo, Seung-Hoi, Ho, Won-Kyung, Kang, Jong-Sun, Kim, Seong-Tae, Cho, Hana
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996652/
https://ncbi.nlm.nih.gov/pubmed/27466704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17159
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