Respective contributions of α-adrenergic and non-adrenergic mechanisms in the hypotensive effect of imidazoline-like drugs

1. The hypotensive effect of imidazoline-like drugs, such as clonidine, was first attributed to the exclusive stimulation of central α(2)-adrenoceptors (α(2)ARs). 2. However, a body of evidence suggests that non-adrenergic mechanisms may also account for this hypotension. 3. This work aims (i) to ch...

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Detalhes bibliográficos
Main Authors: Bruban, Véronique, Feldman, Josiane, Greney, Hugues, Dontenwill, Monique, Schann, Stephan, Jarry, Christian, Payard, Marc, Boutin, Jean, Scalbert, Elizabeth, Pfeiffer, Bruno, Renard, Pierre, Vanhoutte, Paul, Bousquet, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572786/
https://ncbi.nlm.nih.gov/pubmed/11350862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704080
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