Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y

1. We studied the effects of the novel noradrenaline and serotonin (5-HT) reuptake inhibitor sibutramine on feeding and body weight in a rat model of dietary obesity, and whether it interacts with hypothalamic neuropeptide Y (NPY) neurones. 2. Chow-fed and dietary-obese (DIO) male Wistar rats were g...

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Hlavní autoři: Brown, Michael, Bing, Chen, King, Peter, Pickavance, Lucy, Heal, David, Wilding, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572745/
https://ncbi.nlm.nih.gov/pubmed/11309262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704030
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