Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y

1. The thiazolidinedione BRL 49653 (rosiglitazone) induces hyperphagia and weight gain in obese, insulin-resistant fatty Zucker rats but not in lean insulin-sensitive rats. We investigated whether these responses might involve neuropeptide Y (NPY), leptin and insulin. 2. BRL 49653 (1 mg kg(−1) day(−...

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Detalhes bibliográficos
Main Authors: Wang, Qiong, Dryden, Simon, Frankish, Helen M, Bing, Chen, Pickavance, Lucy, Hopkins, David, Buckingham, Robin, Williams, Gareth
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565091/
https://ncbi.nlm.nih.gov/pubmed/9421288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701535
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