Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo

1. Previous studies indicate that 3-nitropropionic acid (3-NPA) neurotoxicity involves the excitotoxic activation of N-methyl-D-aspartate (NMDA) receptors. Thus, we examined the effect of orphenadrine (an anticholinergic drug with NMDA receptor antagonist properties) on 3-NPA neurotoxicity in both c...

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Main Authors: Pubill, David, Verdaguer, Ester, Canudas, Anna Ma, Sureda, Francesc Xavier, Escubedo, Elena, Camarasa, Jordi, Pallàs, Merce, Camins, Antoni
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572610/
https://ncbi.nlm.nih.gov/pubmed/11159722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703869
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