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Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize α(2)-adrenoceptors in the prefrontal cortex
1. This study investigated the effect of acute (2 days) and chronic (14 days) treatment with a selective inhibitor of noradrenaline uptake, reboxetine (10 mg kg(−1) day(−1)) by osmotic pumps, on extracellular noradrenaline and the sensitivity of α(2)-adrenoceptors in the prefrontal cortex of rats. 2...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572559/ https://ncbi.nlm.nih.gov/pubmed/11156576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703821 |
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