Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize α(2)-adrenoceptors in the prefrontal cortex

1. This study investigated the effect of acute (2 days) and chronic (14 days) treatment with a selective inhibitor of noradrenaline uptake, reboxetine (10 mg kg(−1) day(−1)) by osmotic pumps, on extracellular noradrenaline and the sensitivity of α(2)-adrenoceptors in the prefrontal cortex of rats. 2...

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Bibliografiske detaljer
Main Authors: Invernizzi, R W, Parini, S, Sacchetti, G, Fracasso, C, Caccia, S, Annoni, K, Samanin, R
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572559/
https://ncbi.nlm.nih.gov/pubmed/11156576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703821
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