Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration

1. The effects of I(Ks) block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to those of E-4031, a recognized I(Kr) blocker. Measurements were made in rabbit Langendorff-perfused whole hearts, isolated papillary muscle, and...

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Bibliografiska uppgifter
Huvudupphovsmän: Lengyel, Csaba, Iost, Norbert, Virág, László, Varró, András, Lathrop, David A, Papp, Julius Gy
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2001
Ämnen:
Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572535/
https://ncbi.nlm.nih.gov/pubmed/11156566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703777
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