Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration

1. The effects of I(Ks) block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to those of E-4031, a recognized I(Kr) blocker. Measurements were made in rabbit Langendorff-perfused whole hearts, isolated papillary muscle, and...

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Main Authors: Lengyel, Csaba, Iost, Norbert, Virág, László, Varró, András, Lathrop, David A, Papp, Julius Gy
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572535/
https://ncbi.nlm.nih.gov/pubmed/11156566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703777
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