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Selective phenylalkylamine block of I(Kr) over other K(+) currents in guinea-pig ventricular myocytes

1. Previous studies on verapamil and D600 have established that the Ca(2+)-channel blockers also inhibit delayed-rectifier K(+) currents in cardiac tissues and myocytes. However, estimated IC(50) values range over two to three orders of concentration, and it is unclear whether this reflects a high s...

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Autori principali: Jones, Stephen E, Missan, Sergey, Zhabyeyev, Pavel, McDonald, Terence F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572516/
https://ncbi.nlm.nih.gov/pubmed/11139462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703758
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