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Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes.

Single sodium channel openings have been recorded from cell-attached patches of isolated guinea pig ventricular myocytes. A paired pulse protocol was used to test the hypothesis that channel openings are required for lidocaine block. While the averaged ensemble current during the test pulse was much...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McDonald, T V, Courtney, K R, Clusin, W T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1989
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1330590/
https://ncbi.nlm.nih.gov/pubmed/2548633
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