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Properties of the block of single Na+ channels in guinea-pig ventricular myocytes by the local anaesthetic penticainide.

1. The blocking mechanism of a disopyramide derivative Penticainide (2-alkyl-(4-(dialkylamino)-2-)pyridyl-butyramide) on cardiac Na+ channels has been studied using single-channel analysis in cell-attached and inside-out patches from guinea-pig ventricular cells. Penticainide was applied in concentr...

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Detalhes bibliográficos
Main Authors: Carmeliet, E, Nilius, B, Vereecke, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190442/
https://ncbi.nlm.nih.gov/pubmed/2555476
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