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Inhibition of HERG1 K(+) channels by the novel second-generation antihistamine mizolastine

1. Ventricular arrhythmias are rare but life-threatening side effects of therapy with the second-generation H(1) receptor antagonists terfenadine and astemizole. Blockade of the K(+) channels encoded by the Human Ether-à-go-go-Related Gene 1 (HERG1) K(+) channels, which is the molecular basis of the...

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Bibliografske podrobnosti
Main Authors: Taglialatela, Maurizio, Pannaccione, Anna, Castaldo, Pasqualina, Giorgio, Giovanna, Annunziato, Lucio
Format: Artigo
Jezik:Inglês
Izdano: 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572425/
https://ncbi.nlm.nih.gov/pubmed/11082114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703654
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