A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices

1. We have investigated the pharmacological properties of LY344545, a structurally related epimer of the broad spectrum competitive metabotropic glutamate receptor antagonist, LY341495. We have found that LY344545 also antagonizes competitively nearly all mGlu receptor subtypes, but with a wide spec...

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Bibliographische Detailangaben
Hauptverfasser: Doherty, A J, Palmer, M J, Bortolotto, Z A, Hargreaves, A, Kingston, A E, Ornstein, P L, Schoepp, D D, Lodge, D, Collingridge, G L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572327/
https://ncbi.nlm.nih.gov/pubmed/10991916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703574
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