A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices

1. We have investigated the pharmacological properties of LY344545, a structurally related epimer of the broad spectrum competitive metabotropic glutamate receptor antagonist, LY341495. We have found that LY344545 also antagonizes competitively nearly all mGlu receptor subtypes, but with a wide spec...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Doherty, A J, Palmer, M J, Bortolotto, Z A, Hargreaves, A, Kingston, A E, Ornstein, P L, Schoepp, D D, Lodge, D, Collingridge, G L
פורמט: Artigo
שפה:Inglês
יצא לאור: 2000
נושאים:
Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572327/
https://ncbi.nlm.nih.gov/pubmed/10991916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703574
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