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Barnidipine block of L-type Ca(2+) channel currents in rat ventricular cardiomyocytes

1. The effects of barnidipine and nifedipine on L-type Ca(2+) current (I(Ca(L))) were investigated in ventricular cardiomyocytes from rats. 2. Both barnidipine and nifedipine reduced I(Ca(L)) in a concentration and voltage dependent manner; the EC(50) were 80 and 130 nM at a holding potential of −80...

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Detalhes bibliográficos
Main Authors: Wegener, Jörg W, Meyrer, Hans, Rupp, Johanna, Nawrath, Hermann
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572272/
https://ncbi.nlm.nih.gov/pubmed/10952695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703514
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