Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F(2α)-induced periodic contraction of rat uterus

In isolated rat uterine strips, adrenomedullin (AM) inhibited the spontaneous periodic contraction in a concentration-dependent manner (IC(50)=22.3±0.7 nM). The inhibitory effect of AM was prevented by either AM(22–52), a putative antagonist for AM receptors, or calcitonin gene-related peptide (CGRP...

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Dettagli Bibliografici
Autori principali: Yanagita, Toshihiko, Yamamoto, Ryuichi, Sugano, Takashi, Kobayashi, Hideyuki, Uezono, Yasuhito, Yokoo, Hiroki, Shiraishi, Seiji, Minami, Shin-ichi, Wada, Akihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
Soggetti:
Special Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572263/
https://ncbi.nlm.nih.gov/pubmed/10952659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703500
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