Replacement of the carboxylic acid group of prostaglandin F(2α) with a hydroxyl or methoxy substituent provides biologically unique compounds

1. Replacement of the carboxylic acid group of PGF(2α) with the non-acidic substituents hydroxyl (-OH) or methoxy (-OCH(3)) resulted in an unexpected activity profile. 2. Although PGF(2α) 1-OH and PGF(2α) 1-OCH(3) exhibited potent contractile effects similar to 17-phenyl PGF(2α) in the cat lung pare...

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Detalhes bibliográficos
Main Authors: Woodward, D F, Krauss, A H-P, Chen, J, Gil, D W, Kedzie, K M, Protzman, C E, Shi, L, Chen, R, Krauss, H A, Bogardus, A, Dinh, H T T, Wheeler, L A, Andrews, S W, Burk, R M, Gac, T, Roof, M B, Garst, M E, Kaplan, L J, Sachs, G, Pierce, K L, Regan, J W, Ross, R A, Chan, M F
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572247/
https://ncbi.nlm.nih.gov/pubmed/10952685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703462
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