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2′-Fluoro Substituents Can Mimic Native 2′-Hydroxyls within Structured RNA
The ability of fluorine in a C-F bond to act as a hydrogen bond acceptor is controversial. To test such ability in complex RNA macromolecules, we have replaced native 2′-OH groups with 2′-F and 2′-H groups in two related systems, the Tetrahymena group I ribozyme and the ΔC209 P4-P6 RNA domain. In th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167488/ https://ncbi.nlm.nih.gov/pubmed/21867910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.07.014 |
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