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Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels
1. The objective of this investigation was to determine the influence of amygdala kindling on the pharmacodynamics of tiagabine in vivo, using quantitative EEG parameters and extracellular GABA concentrations as pharmacodynamic endpoints. In integrated pharmacokinetic/pharmacodynamic (PK/PD) studies...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572173/ https://ncbi.nlm.nih.gov/pubmed/10882388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703417 |
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