Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat

1. The ‘effect compartment' model was applied to characterize the pharmacodynamics of the R- and S-isomers of tiagabine in conscious rats in vivo using increase in the β activity of the EEG as a pharmacodynamic endpoint. 2. No pharmacokinetic differences in plasma were observed between R- and S...

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Autori principali: Cleton, A, de Greef, H J M M, Edelbroek, P M, Voskuyl, R A, Danhof, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571804/
https://ncbi.nlm.nih.gov/pubmed/10588919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702962
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