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On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein
The stereoselective affinity of small-molecule binding to proteins is typically broadly explained in terms of the thermodynamics of the final bound complex. Using Brownian dynamics simulations, we show that the preferential binding of the MDM2 protein to the geometrical isomers of Nutlin-3, an effec...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905064/ https://ncbi.nlm.nih.gov/pubmed/24270847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27273 |
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