Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock

1. Poly (ADP-ribose) synthetase (PARP) is a nuclear enzyme activated by strand breaks in DNA, which are caused inter alia by reactive oxygen species (ROS). Here we report on (i) a new synthesis of a water-soluble and potent PARP inhibitor, 5-aminoisoquinolinone (5-AIQ) and (ii) investigate the effec...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: McDonald, Michelle C, Mota-Filipe, Helder, Wright, James A, Abdelrahman, Maha, Threadgill, Michael D, Thompson, Andrew S, Thiemermann, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572143/
https://ncbi.nlm.nih.gov/pubmed/10864891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703391
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados