Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock

1. Poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme activated by strand breaks in DNA, which are caused by reactive oxygen species (ROS). Here we investigate the effects of the PARS inhibitors 3-aminobenzamide (3-AB), nicotinamide and 1,5-dihydroxyisoquinoline (ISO) on the circulatory failure...

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Hlavní autoři: McDonald, Michelle C, Filipe, Helder Mota, Thiemermann, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: 1999
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571761/
https://ncbi.nlm.nih.gov/pubmed/10578150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702928
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