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Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline
1. Amitriptyline has been known to induce QT prolongation and torsades de pointes which causes sudden death. We studied the effects of amitriptyline on the human ether-a-go-go-related gene (HERG) channel expressed in Xenopus oocytes and on the rapidly activating delayed rectifier K(+) current (I(Kr)...
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| Main Authors: | , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2000
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571977/ https://ncbi.nlm.nih.gov/pubmed/10742304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703222 |
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