The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates

1. SDZ-RAD, 40-O-(2-hydroxyethyl)-rapamycin, is a novel macrolide immunosuppressant. Because of its synergistic interaction, SDZ-RAD is under clinical investigation as immunosuppressant in combination with cyclosporine after organ transplantation. Neurotoxicity is a critical side-effect of cyclospor...

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Bibliographic Details
Main Authors: Serkova, Natalie, Litt, Lawrence, Leibfritz, Dieter, Hausen, Bernard, Morris, Randall E, James, Thomas L, Benet, Leslie Z, Christians, Uwe
Format: Artigo
Language:Inglês
Published: 2000
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571863/
https://ncbi.nlm.nih.gov/pubmed/10711346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703079
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