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Nociceptin and the ORL-1 ligand [Phe(1)ψ (CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) exert anti-opioid effects in the Freund's adjuvant-induced arthritic rat model of chronic pain
1. Stimulation of the opioid receptor-like1 (ORL-1) receptor by nociceptin (NC) produces hyperalgesia and reverses the antinociceptive effects induced by opioids. Most studies concerning the central effects of NC were conducted using acute pain models. The role NC may play in chronic inflammation re...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1999
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571738/ https://ncbi.nlm.nih.gov/pubmed/10578139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702884 |
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