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Nociceptin and the ORL-1 ligand [Phe(1)ψ (CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) exert anti-opioid effects in the Freund's adjuvant-induced arthritic rat model of chronic pain

1. Stimulation of the opioid receptor-like1 (ORL-1) receptor by nociceptin (NC) produces hyperalgesia and reverses the antinociceptive effects induced by opioids. Most studies concerning the central effects of NC were conducted using acute pain models. The role NC may play in chronic inflammation re...

詳細記述

保存先:
書誌詳細
主要な著者: Bertorelli, Rosalia, Corradini, Laura, Rafiq, Kamran, Tupper, Joanna, Calò, Girolamo, Ongini, Ennio
フォーマット: Artigo
言語:Inglês
出版事項: 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571738/
https://ncbi.nlm.nih.gov/pubmed/10578139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702884
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