Evidence for 5-HT(7) receptors mediating relaxation of human colonic circular smooth muscle

5-HT(4) receptors mediate relaxation of human colon circular muscle. However, after 5-HT(4) receptor blockade (SB 204070 10 nM), 5-HT still induced a relaxation (pEC(50) 6.3). 5-HT(4) receptors were sufficiently blocked, as the curves to 5-HT obtained in the presence of 10 and 100 nM SB 204070 were...

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Bibliografske podrobnosti
Main Authors: Prins, Nicolaas H, Briejer, Michel R, Van Bergen, Patrick J E, Akkermans, Louis M A, Schuurkes, Jan A J
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Special Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571702/
https://ncbi.nlm.nih.gov/pubmed/10556917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702762
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