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Novel strategies for the design of receptor-selective vasopressin analogues: Aib-substitution and retro-inverso transformation
1. We determined the pharmacological profile of novel backbone-modified peptides designed as protease-resistant, selective analogues of AVP. Binding affinities of peptides were determined at both V(1A) and V(2) subtypes of vasopressin receptor (VPR). Biological potencies of selected peptides were te...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571696/ https://ncbi.nlm.nih.gov/pubmed/10516644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702857 |
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