Anti-spasmogenic activity of isoenzyme-selective phosphodiesterase inhibitors in guinea-pig trachealis

1. The anti-spasmogenic potential of SK&F 94120 (PDE3-selective), rolipram (PDE4-selective), zaprinast (PDE5-selective), zardaverine (dual PDE3/4 inhibitor) and theophylline (non-selective) was evaluated in guinea-pig trachealis. 2. SK&F 94120 or rolipram (10 and 100 μM) antagonized histamin...

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Bibliografiske detaljer
Main Authors: Bernareggi, Micaela M, Belvisi, Maria G, Patel, Hema, Barnes, Peter J, Giembycz, Mark A
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571632/
https://ncbi.nlm.nih.gov/pubmed/10510442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702779
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