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Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors

1. The cyclic AMP phosphodiesterases (PDE) in guinea-pig peritoneal macrophages were isolated, partially characterized and their role in regulating the cyclic AMP content in intact cells evaluated. 2. Differential centrifugation of macrophage lysates revealed that ∼90% of the PDE activity was membra...

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Bibliografski detalji
Glavni autori: Kelly, John J, Barnes, Peter J, Giembycz, Mark A
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565372/
https://ncbi.nlm.nih.gov/pubmed/9630352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701819
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