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Involvement of phospholipid signal transduction pathways in morphine tolerance in mice
1. Opioid tolerance involves an alteration in the activity of intracellular kinases such as cyclic AMP-dependent protein kinase (PKA). Drugs that inhibit PKA reverse morphine antinociceptive tolerance. The hypothesis was tested that phospholipid pathways are also altered in morphine tolerance. Inhib...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571610/ https://ncbi.nlm.nih.gov/pubmed/10498855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702771 |
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