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Structural requirements of sulphonylureas and analogues for interaction with sulphonylurea receptor subtypes
1. The structure-activity relationship for hypoglycaemic sulphonylureas and analogues was examined. Binding affinities were compared using membranes from HIT-T15 cells (β-cell line) and from COS-7 cells transiently expressing sulphonylurea receptor subtypes (SUR1, SUR2A and SUR2B). Inhibition of ade...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571605/ https://ncbi.nlm.nih.gov/pubmed/10498831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702763 |
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