Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats

1. Cyclic guanosine 3′–5′-monophosphate (cyclic GMP) is the second messenger of important physiologically active mediators controlling the pulmonary vascular tone. To potentiate the effects of cyclic GMP on the pulmonary vasculature, we used DMPPO, a new selective PDE-5 inhibitor, and examined its a...

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Main Authors: Eddahibi, Saadia, Raffestin, Bernadette, Le Monnier de Gouville, Anne-Charlotte, Adnot, Serge
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571014/
https://ncbi.nlm.nih.gov/pubmed/9831902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702124
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