A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR

Alveolar rhabdomyosarcoma (ARMS) is an aggressive myogenic-type tumor and a gain-of-function disease, caused by misexpression of the PAX3-FKHR or PAX7-FKHR fusion oncoprotein from structurally rearranged chromosomes. PAX3-FKHR misexpressed in terminally differentiating mouse myofibers can cause rhab...

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Bibliographic Details
Main Authors: Galindo, Rene L., Allport, Jay A., Olson, Eric N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569182/
https://ncbi.nlm.nih.gov/pubmed/16938866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605926103
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