Chemical cleavage reactions of DNA on solid support: application in mutation detection

BACKGROUND: The conventional solution-phase Chemical Cleavage of Mismatch (CCM) method is time-consuming, as the protocol requires purification of DNA after each reaction step. This paper describes a new version of CCM to overcome this problem by immobilizing DNA on silica solid supports. RESULTS: D...

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Veröffentlicht in:	BMC Chem Biol
Hauptverfasser:	Bui, Chinh T, Lambrinakos, Andreana, Babon, Jeffrey J, Cotton, Richard GH
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2003
Schlagworte:	Methodology Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156887/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12744723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1472-6769-3-1
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