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Loss of amplified genes by poly(ADP-ribose) polymerase inhibitors.

A poly(ADP-ribose) polymerase inhibitor, benzamide (BA), was found to induce flat revertants of NIH 3T3 cells that had been transformed by human Ha-ras, rat Ki-ras, rat c-raf, and human ret-II. These genes had been amplified in original transformants, but they were completely eliminated by BA. Contr...

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Autors principals: Nagao, M, Nakayasu, M, Aonuma, S, Shima, H, Sugimura, T
Format: Artigo
Idioma:Inglês
Publicat: 1991
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568072/
https://ncbi.nlm.nih.gov/pubmed/1773788
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