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Ouabain affinity determining residues lie close to the Na/K pump ion pathway
The Na/K pump establishes essential ion concentration gradients across animal cell membranes. Cardiotonic steroids, such as ouabain, are specific inhibitors of the Na/K pump. We exploited the marine toxin, palytoxin, to probe both the ion translocation pathway through the Na/K pump and the site of i...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1567927/ https://ncbi.nlm.nih.gov/pubmed/16894161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602720103 |
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