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Protonation of key acidic residues is critical for the K(+)-selectivity of the Na/K pump

The sodium-potassium (Na/K) pump is a P-type ATPase that generates Na(+) and K(+) concentration gradients across the cell membrane. For each ATP molecule, the pump extrudes three Na(+) and imports two K(+) by alternating between outward- and inward-facing conformations that preferentially bind K(+)...

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Detalhes bibliográficos
Main Authors: Yu, Haibo, Ratheal, Ian, Artigas, Pablo, Roux, Benoît
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190665/
https://ncbi.nlm.nih.gov/pubmed/21909093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2113
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