Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid

Bcl-2 family proteins play a crucial role in tissue homeostasis and apoptosis (programmed cell death). Bid is a proapoptotic member of the Bcl-2 family, promoting cell death when activated by caspase-8. Following an NMR-based approach (structure–activity relationships by interligand NOE) we were abl...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Becattini, Barbara, Culmsee, Carsten, Leone, Marilisa, Zhai, Dayong, Zhang, Xiyun, Crowell, Kevin J., Rega, Michele F., Landshamer, Stefan, Reed, John C., Plesnila, Nikolaus, Pellecchia, Maurizio
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567925/
https://ncbi.nlm.nih.gov/pubmed/16891420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603460103
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares