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Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid
Bcl-2 family proteins play a crucial role in tissue homeostasis and apoptosis (programmed cell death). Bid is a proapoptotic member of the Bcl-2 family, promoting cell death when activated by caspase-8. Following an NMR-based approach (structure–activity relationships by interligand NOE) we were abl...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1567925/ https://ncbi.nlm.nih.gov/pubmed/16891420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603460103 |
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