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Nitric oxide activation of guanylyl cyclase in cells revisited

Nitric oxide (NO) elicits physiological effects in cells largely by activating guanylyl cyclase (GC)-coupled receptors, leading to cGMP accumulation. Like other receptor-coupled effector mechanisms, NO stimulation of GC activity was previously considered to be a graded, concentration-dependent respo...

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Bibliographic Details
Main Authors: Roy, Brijesh, Garthwaite, John
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567716/
https://ncbi.nlm.nih.gov/pubmed/16882726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602544103
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