RS-127445: a selective, high affinity, orally bioavailable 5-HT(2B) receptor antagonist

1. Efforts to define precisely the role of 5-HT(2B) receptors in normal and disease processes have been hindered by the absence of selective antagonists. To address this deficiency, we developed a series of naphthylpyrimidines as potentially useful 5-HT(2B) receptor antagonists. 2. RS-127445 (2-amin...

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Bibliografiske detaljer
Main Authors: Bonhaus, Douglas W, Flippin, Lee A, Greenhouse, Robert J, Jaime, Saul, Rocha, Cindy, Dawson, Mark, Van Natta, Kristine, Chang, L K, Pulido-Rios, Tess, Webber, Andrea, Leung, Edward, Eglen, Richard M, Martin, Graeme R
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566110/
https://ncbi.nlm.nih.gov/pubmed/10455251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702632
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